The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes. Conclusion: Compared with atorvastatin, rosuvastatin produced greater reductions in LDL-C, which may offer advantages in LDL-C goal attainment over existing lipid-lowering therapies. At 52 weeks, compared with atorvastatin, both initial rosuvastatin treatment groups significantly reduced LDL-C (47% and 53% vs 44%, P <.05 and P <.001). Background: Little is known about the differences between standard-dose statins effects on glucose level and lipids in Japanese patients with diabetes mellitus (DM). However, its effect on reduction of serum total cholesterol, TG, and HDL-C is the same as atorvastatin. Compare Crestor vs Lipitor head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Crestor rated 6.0/10 vs Lipitor rated 4.8/10 in overall patient satisfaction. rosuvastatin versus atorvastatin No language restrictions 25 RCTs (n=19,621) resulting in: 28 comparisons of 1:1 dose ratios 20 comparisons of 1:2 dose ratios 6 comparisons of 1:4 dose ratios of rosuvastatin vs. atorvastatin 10 of 25 trials were double blinded Mean study follow-up: 8.6 weeks Law et al. Atorvastatin 5 mg 10 to 20 mg 40 to 80 mg Rosuvastatin Not possible 5 to 10 mg 20 mg Statin plus ezetimibe Not possible Simvastatin 10 mg and ... Age Especially those over 80 years and more often in women Small body frame and frail Some people’s genes make them more likely to get achy muscles Statins are a class of prescription drugs that help to lower cholesterol.They block the enzyme that the body uses to make cholesterol in the liver.
2004 Nov;26(11):1821-33. doi: 10.1016/j.clinthera.2004.11.015.Zhu JR, Tomlinson B, Ro YM, Sim KH, Lee YT, Sriratanasathavorn C.Curr Med Res Opin. (2003)10 To determine effects of statin At 12 weeks, both rosuvastatin dosages brought more patients to within ATP-II and European LDL-C goals than atorvastatin (86% and 89% vs 73% and 75%, and 86% vs 55%, respectively). We believe that the available body of evidence indicates that atorvastatin may have several advantages over rosuvastatin, despite the latter's greater potency, suggesting that atorvastatin should be the potent statin of choice, especially in treating patients with renal impairment or heart failure with concomitant coronary artery disease. Methods and results: The 1,049 patients were randomly assigned to either the rosuvastatin group or atorvastatin group.
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