Statins are considered very effective in reducing cardiovascular morbidity and mortality in high-risk patients. “It's finding the sweet spot of what works for every patient." 15. If statin side effects become an issue, the prescription can often be tweaked. Lancet. Roughly 5% to 10% of statin users develop statin intolerance, and because statin use is expected to increase--especially after recent updated guidelines have expanded the statin benefit groups--adverse effects from statins will become a growing issue. Guidance For Managing Suspected Statin Intolerance Background Statin intolerance is defined as “the presense of clinically significant adverse effects from statin therapy that are considered to represent an unacceptable risk to the patient or that may result in compliance with … In recent years statins have become an established option in lipid-lowering pharmacotherapy despite the fact that statin intolerance is fairly common. However, although adherence to statins improves morbidity and mortality (1), it remains suboptimal (2). Indeed statin discontinuation is significantly associated with negative media coverage. statin intolerant ’ too quickly. Definition of Statin Intolerance •Intolerance to initial statin therapy is defined by NICE as the presence of clinically significant adverse effects that represent an unacceptable risk to Ridker PM, Cook NR. Statin intolerance occurs when a person develops side effects from statin use. Statins: new American guidelines for prevention of cardiovascular disease. “For most people who say that they're statin intolerant, there's usually an option,” says Orkaby, who adds that there are some that are considered lower or moderate intensity. There are different symptoms you may experience. One of the most important causes of nonadherence is the so-called statin intolerance, mainly because of muscle-related symptoms. For the Supplementary Data which include background information and detailed discussion of the data that have provided the basis for the Guidelines see https:// The most common is muscle pains or … 2013;382(9907):1762–1765. When muscle pains and/or an elevation of the creatine kinase appear, the dose must be lowered in patients with slight symptoms or stopped altogether if the symptoms are more severe.
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