From: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015. This causative agent is carried by Tsetse flies that causes the most severe form of illness. Sleeping sickness is characterized by two stages of illness. These organisms differ in transmission and how infections are diagnosed and treated, and … Conversely, Rhodesian HAT (rHAT), caused by Trypanosoma brucei rhodesiense, is a zoonosis with occasional human infection, and represents less than 3% of all HAT cases. The infection carried by Tsetse fly spreads through the blood after the fly bites are encountered. Trypanosoma Brucei Rhodesiense. Other articles where Trypanosoma brucei rhodesiense is discussed: sleeping sickness: … or the closely related subspecies T. brucei rhodesiense, transmitted by the tsetse fly (genus Glossina). In the first stage, infected persons typically experience fever, headache, muscle and joint pain, and inflammation of the lymph nodes Despite these successes, concern has increased recently regarding potential convergence of the 2 causes of HAT (Trypanosoma brucei gambiense and T. brucei rhodesiense). Trypanosoma brucei rhodesiense causes the acute form of African sleeping sickness and is acquired from tsetse fly bites, typically in association with game and brush in eastern and southern Africa. Currently, global HAT case numbers are reaching less than 1 case per … Sleeping sickness is caused due to parasitic causative agent called Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. by Gala Garrod, Emily R. Adams, Jessica K. Lingley, Isabel Saldanha, Stephen J. Torr, Lucas J. Cunningham Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies.