what is the most efficacious statin

 |  Cleveland—A new study documents muscle-related symptoms in patients with a history of statin-intolerance and determines which drug is a more effective option to lower their cholesterol. Please enable it to take advantage of the complete set of features! Reproduction in whole or in part without permission is prohibited. Expert Opin Investig Drugs. Rosuvastatin, like atorvastatin, has a plasma half-life of about 20 h and is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. 2004 Nov;26(11):1821-33. doi: 10.1016/j.clinthera.2004.11.015. Clin Ther. Epub 2017 Dec 5. COVID-19 is an emerging, rapidly evolving situation. Curr Med Res Opin. Pharmacotherapy. 2020 Jul 2;21(13):4725. doi: 10.3390/ijms21134725. In a Phase II study, rosuvastatin across a dose range of 1- 80 mg lowered low-density lipoprotein cholesterol (LDL-C) by 34 - 65%. 2016 Jun 6;7(9):1163-8. doi: 10.7150/jca.14941. Click here to return to Weekly News Update. Statins are drugs that can reduce levels of cholesterol in the blood. Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights.  |  USA.gov. 1 Simvastatin is the most lipophilic statin. Efforts to define the genetic architecture underlying variable statin response have met with limited success possibly because previous studies were limited to effect based on one-single-dose. Get the latest research from NIH: https://www.nih.gov/coronavirus. 2006 Apr;26(4):469-78. doi: 10.1592/phco.26.4.469. The claim regarding LDL lowering is erroneous as pitavastatin is actually more efficacious … doi: 10.5812/ijem.43319. Statins can be used in combination with other lipid-lowering drugs depending upon the lipid-profile of the patient or if a … Investigation of the Bioequivalence of Rosuvastatin 20 mg Tablets after a Single Oral Administration in Mediterranean Arabs Using a Validated LC-MS/MS Method. eCollection 2016. Effects of Different Types of Statins on Lipid Profile: A Perspective on Asians. Int J Endocrinol Metab. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. 2005 Aug;21(8):1307-15. doi: 10.1185/030079905X56529. Clipboard, Search History, and several other advanced features are temporarily unavailable. Twelve-week, multicenter, randomized, open-label comparison of the effects of rosuvastatin 10 mg/d and atorvastatin 10 mg/d in high-risk adults: a DISCOVERY study. J Am Acad Dermatol. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia Expert Opin Investig Drugs . HHS Anothaisintawee T, Udomsubpayakul U, McEvoy M, Lerdsitthichai P, Attia J, Thakkinstian A. J Cancer. The DISCOVERY PENTA study: a DIrect Statin COmparison of LDL-C Value--an Evaluation of Rosuvastatin therapY compared with atorvastatin. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Galicia-Garcia U, Jebari S, Larrea-Sebal A, Uribe KB, Siddiqi H, Ostolaza H, Benito-Vicente A, Martín C. Int J Mol Sci. Statins study guide by nammik includes 30 questions covering vocabulary, terms and more. A Primer for Pharmacists (ARCHIVED), Uncovering Estrogen’s Role in CVD Protection in Premenopausal Women, Burdensome Preauthorization Process Limits Prescriptions for PCSK9 Inhibitors for Hypercholesterolemia, Guideline-Preferred Diuretic, Chlorthalidone, Causes More Serious Side Effects, Cardiovascular Considerations With Prescription Opioids for Chronic Pain. NIH NLM Rosuvastatin is a synthetic enantiomer that is hepatoselective, relatively hydrophilic and has minimal metabolism via the cytochrome P450 3A4 system (similar to pravastatin). eCollection 2017 Apr. The National Lipid Association (NLA) defines myopathy as symptoms of myalgia in addition to an elevation in serum creatine kinase (CK) greater than 10 times the upper limit of normal (CK >10 × ULN). We leveraged electronic medical records (EMRs) to extract potency (ED 50) and efficacy (E max) of statin dose-response curves and tested them for association with 144 pre-selected variants. Fonseca FA, Ruiz A, Cardona-Muñoz EG, Silva JM, Fuenmayor N, Marotti M; DISCOVERY PENTA investigators. Synonym Discussion of efficacious. Lipophilic statins penetrate muscle more easily than hydrophilic statins and are associated with a higher incidence of adverse effects, particularly myopathy, although reports of muscle toxicity, including rhabdomyolisis have been reported with all statins. Most providers used every statin for years before there were outcomes! Uploaded By SuperHumanRockPenguin8884. The majority of HMG-CoA reductase inhibitory activity in plasma is associated with the parent rosuvastatin compound. 2017 Apr 22;15(2):e43319. Zaid AN, Al Ramahi R, Cortesi R, Mousa A, Jaradat N, Ghazal N, Bustami R. Sci Pharm. 2002 Jan;11(1):125-41. doi: 10.1517/13543784.11.1.125. Efficacious definition is - having the power to produce a desired effect. Author Michael H Davidson 1 Affiliation 1 … The drug appears to be well tolerated at all doses up to 80 mg/day. Learn about the types, their uses, and the risks of taking statins here. Evidence-Based Treatment of Hypercholesterolemia: Patient-Centered Evaluation and Management, What do we Currently Know about the Cardiovascular Benefits of GLP-1 RAs? National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. This site needs JavaScript to work properly. The report, published recently by JAMA and simultaneously presented at the American College of Cardiology’s 65th Annual Scientific Session in Chicago, is the first major trial of its kind. Bullano MF, Wertz DA, Yang GW, Kamat S, Borok GM, Gandhi S, McDonough KL, Willey VJ. Allison B. Goldfine, M.D. Lin BM, Li WQ, Cho E, Curhan GC, Qureshi AA. 2016 Jun 30;84(3):536-546. doi: 10.3390/scipharm84030536. Interview with Dr. Allison Goldfine on statins, the associated risk of diabetes, and the FDA’s response. 2003 Nov;1(4):495-505. doi: 10.1586/14779072.1.4.495. 2002 Mar;11(3):455. Get the latest public health information from CDC: https://www.coronavirus.gov. Notes. Myopathy is defined in various ways. The most efficacious statin is rosuvastatin. Strandberg TE, Feely J, Sigurdsson EL; DISCOVERY study group. 2002 Mar;11(3):125-41. Which statin is the most potent rosuvastatin which School Western University; Course Title PHARM 4350a; Type. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia Expert Opin Investig Drugs. Thus rosuvastatin was the most efficacious of all the statins, followed by atorvastatin and simvastatin Table 1).15 The STELLAR study8 also revealed that the Adult Treatment Panel III LDL cholesterol goal was achieved by 82% to 89% of patients treated with rosuvastatin 10 to 40 mg compared with 69% to 85% of patients treated with atorvastatin 10 to 80 mg. Expert Rev Cardiovasc Ther. Effect of Lipophilic and Hydrophilic Statins on Breast Cancer Risk in Thai Women: A Cross-sectional Study. Meor Anuar Shuhaili MFR, Samsudin IN, Stanslas J, Hasan S, Thambiah SC. 2018 Apr;78(4):682-693. doi: 10.1016/j.jaad.2017.11.050. All rights reserved. Rosuvastatin: a new inhibitor of HMG-coA reductase for the treatment of dyslipidemia. The American College of Cardiology (ACC), American Heart Association (AHA), and National Heart, Lung, and Blood Institute (NHLBI) use myopathy as a general term referring to any disease of the muscles, which is the most common definition.2  |  Phase III trials have demonstrated greater reductions in LDL-C for rosuvastatin compared to atorvastatin as well as greater increases in high-density lipoprotein cholesterol (HDL-C). How to use efficacious in a sentence. Effect of rosuvastatin compared with other statins on lipid levels and National Cholesterol Education Program goal attainment for low-density lipoprotein cholesterol in a usual care setting. 2002 Jan;11(1):125-41. doi: 10.1517/13543784.11.1.125. Quizlet flashcards, activities and games help you improve your grades. These structural properties render this statin the most efficient in terms of dose able to reduce HMG-CoA reductase activity by 50% (Davidson, 2002). Expert Opin Investig Drugs. A starting dose of 10 mg will reduce LDL-C by approximately 50%, which should adequately treat most patients to within the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) goals. Copyright © 2000 - 2020 Jobson Medical Information LLC unless otherwise noted.

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